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Handbook of neuroemergency clinical trials

Record Type:	Electronic resources : Monograph/item
Title/Author:	Handbook of neuroemergency clinical trials/ edited by Wayne M. Alves, Brett E. Skolnick.
other author:	Alves, Wayne M.
Published:	Amsterdam ;Elsevier Academic Press, : c2006.,
Description:	1 online resource (xviii, 336 p.) :ill. :
Subject:	Nervous system - Diseases -
Online resource:	http://www.sciencedirect.com/science/book/9780120885237
ISBN:	9780120885237

Handbook of neuroemergency clinical trials
Handbook of neuroemergency clinical trials[electronic resource] /edited by Wayne M. Alves, Brett E. Skolnick. - Amsterdam ;Elsevier Academic Press,c2006. - 1 online resource (xviii, 336 p.) :ill.

Includes bibliographical references and index.

Foreword -- Section-I Uses, Abuses & Epidemiology -- Section-II Pharmacokinetics & Metabolism -- Section-III Esterases, Receptors, Mechanisms & Tolerance Development -- Section-IV Organ Toxicity -- Section-V Non-Specific Toxic Effects -- Section-VI Risk Assessment & Regulations -- Section-VII Aquatic & Wildlife -- Section-VIII Analytical & Biomarkers -- Section-IX Therapeutic Measures.

This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.-Describes everything you need to know about Organophosphates and Carbamates -Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants -Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates -Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases -Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity -Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis -Provides in vitro and in vivo models for neurotoxicity testing -Integrates knowledge of studies in lab animals and humans -Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues -Describes management of Anticholinesterase poisoning in humans.

ISBN: 9780120885237

Source: 108158:108201Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

76074
Nervous system
--DiseasesIndex Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RC346 / .H2355 2006eb

Dewey Class. No.: 616.8/0461

National Library of Medicine Call No.: 2006 B-730

Handbook of neuroemergency clinical trials
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245 0 0 $a Handbook of neuroemergency clinical trials $h [electronic resource] / $c edited by Wayne M. Alves, Brett E. Skolnick.
260 $a Amsterdam ; $a Boston : $c c2006. $b Elsevier Academic Press,
300 $a 1 online resource (xviii, 336 p.) : $b ill.
504 $a Includes bibliographical references and index.
505 0 $a Foreword -- Section-I Uses, Abuses & Epidemiology -- Section-II Pharmacokinetics & Metabolism -- Section-III Esterases, Receptors, Mechanisms & Tolerance Development -- Section-IV Organ Toxicity -- Section-V Non-Specific Toxic Effects -- Section-VI Risk Assessment & Regulations -- Section-VII Aquatic & Wildlife -- Section-VIII Analytical & Biomarkers -- Section-IX Therapeutic Measures.
505 0 $a Acute ischemic stroke / Christopher Bladin and Stephen Davis -- Subarachnoid hemorrhage / Nader Pouratian, Aaron S. Dumont, and Neal F. Kassell -- Spontaneous intracerebral hemorrhage / Michael D. Hill -- Traumatic brain injury / Wayne M. Alves and Lawrence F. Marshall -- Acute seizures and status epilepticus / Susan Herman -- Clinical trials in neuro-ophthalmology / Madhura Tamhankar and Laura Balcer -- Brain resuscitation / Edwin Nemoto and Charles C. King -- Clinical trials in brain injury after cardiac arrest / Romergryko G. Geocadin and Daniel F. Hanley.
505 0 $a Efficient dose-response finding strategies for acute neuroemergency treatments / Tom Parke ... [et al.] -- Biostatistical issues in neuroemergency clinical trials / Wayne M. Alves -- Data safety and monitoring board: role in acute neurological trials / Brett E. Skolnick -- Role of a project medical officer in acute neuroemergency clinical trials / Joseph A. Kwentus -- Ethical considerations in neuroemergency clinical trials / Wayne M. Alves -- Industry perspective on drug development / Thomas C. Wessel and Christopher Gallen -- Regulatory perspective / Lisa L. Travis.
520 $a This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.-Describes everything you need to know about Organophosphates and Carbamates -Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants -Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates -Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases -Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity -Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis -Provides in vitro and in vivo models for neurotoxicity testing -Integrates knowledge of studies in lab animals and humans -Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues -Describes management of Anticholinesterase poisoning in humans.
588 $a Description based on print version record.
650 0 $a Nervous system $x Diseases $3 76074
650 0 $a Neuropharmacology $v Handbooks, manuals, etc. $3 255376
650 0 $a Clinical trials $v Handbooks, manuals, etc. $3 255377
650 1 2 $a Central Nervous System Diseases $x drug therapy. $3 255378
650 1 2 $a Neuroprotective Agents $x therapeutic use. $3 255379
650 2 2 $a Clinical Trials $x methods. $3 72848
650 2 2 $a Emergency Medicine $x methods. $3 92241
650 2 2 $a Neuropharmacology $x methods. $3 255380
650 6 $a Systeme nerveux $x Maladies $v Guides, manuels, etc. $3 255381
650 6 $a Neuropharmacologie $v Guides, manuels, etc. $3 255382
650 6 $a Etudes cliniques $v Guides, manuels, etc. $3 255383
655 4 $a Electronic books. $2 local. $3 96803
700 1 $a Alves, Wayne M. $3 255374
700 1 $a Skolnick, Brett Evan. $3 255375
776 0 8 $i Print version: $t Handbook of neuroemergency clinical trials. $d Amsterdam ; Boston : Elsevier Academic Press, c2006 $z 0126480826 $z 9780126480825 $w (DLC) 2005027031 $w (OCoLC)61692694
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780120885237