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The molecular basis of cancer

Record Type:	Electronic resources : Monograph/item
Title/Author:	The molecular basis of cancer/ [edited by] John Mendelsohn ... [et al.].
other author:	Mendelsohn, John,
Published:	Philadelphia, PA :Saunders/Elsevier, : c2008.,
Description:	xix, 757 p. :col. ill. ; : 29 cm.;
Subject:	Cancer - Molecular aspects. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9781416037033

The molecular basis of cancer
The molecular basis of cancer[electronic resource] /[edited by] John Mendelsohn ... [et al.]. - 3rd ed. - Philadelphia, PA :Saunders/Elsevier,c2008. - xix, 757 p. :col. ill. ;29 cm.

Includes bibliographical references and index.

Cancer: a genetic disorder -- Oncogenes and signal transduction -- Tumor suppressor genes -- DNA repair pathways and human cancer -- Epigenetics and cancer -- Infectious agents and cancer -- Environmental carcinogenesis -- Animal models: flies, fish, and yeast -- Genetic mosue models of cancer -- Cancer stem cells -- Signal transduction by growth factor receptors -- Cell growth -- Regulation of the cell cycle -- Metabolism of cell growth and proliferation -- Apoptosis, autophagy, and necrosis -- Cellular senescence -- The tumor microenvironment in cancer progression -- Tumor angiogenesis -- Invasion and metastasis -- Cancer genomics -- Transcriptome analysis -- Mass spectrometry in cancer biology -- Imaging and cancer -- Bioinformatics -- Early detection of cancer: molecular screening -- Lymphoma/myeloma -- Molecular genetics of ALL -- Biology of chronic and acute myeloid leukemia -- Molecular biology of childhood neoplasms -- Molecular basis of lung cancer -- Molecular abnormalities in colon and rectal cancer -- Breast cancer -- Molecular basis of prostate cancer -- Molecular pathogenesis of epithelial ovarian cancer -- Molecular pathogenesis of pancreatic adenocarcinoma -- Molecular biology of melanoma -- Soft-tissue sarcomas -- Head and neck squamous cell carcinoma -- Primary brain tumors -- Epithelial skin cancer -- Endocrine cancer -- Gastric and gastroesophageal adenocarcinoma -- From bench to bedside with targeted therapies -- Screening strategies for targeted therapeutics -- Animal models to predict anticancer efficacy -- Pharmacokinetics, pharmacodynamics, and pharmacogenetics -- Phase 1 trials today -- Cancer therapeutics -- Natural and acquired resistance to cancer therapies -- Molecular basis of radiation therapy -- Hematopoietic growth factors and cytokines -- Interferons -- Cancer and the cellular immune response -- Cancer-specific vaccines -- Monoclonal antibody therapy of cancer -- Gene therapy and oncolytic viruses -- RNA as a therapeutic molecule -- Heat shock protein 90 and the proteasome -- Cancer chemoprevention.

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and now as an Expert Consult title, it enables you to conveniently search the entire text online, download all of the book b2 ss images for your personal use, and review periodic updates. Offers online access the book's complete contents b7 sfully searchable b7 salong with periodic updates, and artwork from the text for your personal use. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures b7 sall redrawn in full color b7 sillustrating major concepts for easier comprehension.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2009.

Mode of access: World Wide Web.

ISBN: 9781416037033

Source: 30730:30732Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

120670
Cancer
--Molecular aspects.Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RC268.5 / .M632 2008

Dewey Class. No.: 616.99/4071

National Library of Medicine Call No.: 2008 F-244

The molecular basis of cancer
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245 0 4 $a The molecular basis of cancer $h [electronic resource] / $c [edited by] John Mendelsohn ... [et al.].
250 $a 3rd ed.
260 $a Philadelphia, PA : $c c2008. $b Saunders/Elsevier,
300 $a xix, 757 p. : $b col. ill. ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a Cancer: a genetic disorder -- Oncogenes and signal transduction -- Tumor suppressor genes -- DNA repair pathways and human cancer -- Epigenetics and cancer -- Infectious agents and cancer -- Environmental carcinogenesis -- Animal models: flies, fish, and yeast -- Genetic mosue models of cancer -- Cancer stem cells -- Signal transduction by growth factor receptors -- Cell growth -- Regulation of the cell cycle -- Metabolism of cell growth and proliferation -- Apoptosis, autophagy, and necrosis -- Cellular senescence -- The tumor microenvironment in cancer progression -- Tumor angiogenesis -- Invasion and metastasis -- Cancer genomics -- Transcriptome analysis -- Mass spectrometry in cancer biology -- Imaging and cancer -- Bioinformatics -- Early detection of cancer: molecular screening -- Lymphoma/myeloma -- Molecular genetics of ALL -- Biology of chronic and acute myeloid leukemia -- Molecular biology of childhood neoplasms -- Molecular basis of lung cancer -- Molecular abnormalities in colon and rectal cancer -- Breast cancer -- Molecular basis of prostate cancer -- Molecular pathogenesis of epithelial ovarian cancer -- Molecular pathogenesis of pancreatic adenocarcinoma -- Molecular biology of melanoma -- Soft-tissue sarcomas -- Head and neck squamous cell carcinoma -- Primary brain tumors -- Epithelial skin cancer -- Endocrine cancer -- Gastric and gastroesophageal adenocarcinoma -- From bench to bedside with targeted therapies -- Screening strategies for targeted therapeutics -- Animal models to predict anticancer efficacy -- Pharmacokinetics, pharmacodynamics, and pharmacogenetics -- Phase 1 trials today -- Cancer therapeutics -- Natural and acquired resistance to cancer therapies -- Molecular basis of radiation therapy -- Hematopoietic growth factors and cytokines -- Interferons -- Cancer and the cellular immune response -- Cancer-specific vaccines -- Monoclonal antibody therapy of cancer -- Gene therapy and oncolytic viruses -- RNA as a therapeutic molecule -- Heat shock protein 90 and the proteasome -- Cancer chemoprevention.
520 $a Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. A new full-color format expedites reference, and now as an Expert Consult title, it enables you to conveniently search the entire text online, download all of the book b2 ss images for your personal use, and review periodic updates. Offers online access the book's complete contents b7 sfully searchable b7 salong with periodic updates, and artwork from the text for your personal use. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures b7 sall redrawn in full color b7 sillustrating major concepts for easier comprehension.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2009. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Dec. 9, 2009). $n Access may be restricted to users at subscribing institutions.
650 0 $a Cancer $x Molecular aspects. $3 120670
650 0 $a Carcinogenesis. $3 120648
650 1 2 $a Neoplasms $x genetics. $3 226571
650 2 2 $a Molecular Biology. $3 93391
655 7 $a Electronic books. $2 local. $3 96803
700 1 $a Mendelsohn, John, $d 1936- $3 292386
710 2 $a ScienceDirect (Online service) $3 254709
776 1 $c Original $z 9781416037033 $z 1416037039 $w (DLC) 2007042086 $w (OCoLC)174094395
856 4 0 $3 ScienceDirect $u http://www.mdconsult.com/public/book/view?title=Mendelsohn:+The+Molecular+Basis+of+Cancer $z An electronic book accessible through the World Wide Web; click for information
856 4 1 $3 Table of contents only $u http://www.loc.gov/catdir/toc/ecip082/2007042086.html
994 $a C0 $b TEF