新生學校財團法人新生醫護管理專科學校圖書館 |

A short history of the drug receptor concept

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	A short history of the drug receptor concept/ Cay-Rèudiger Prèull, Andreas-Holger Maehle, Robert Francis Halliwell.
作者:	Prèull, Cay-Rèudiger.
其他作者:	Maehle, Andreas-Holger,
出版者:	Basingstoke [England] ;Palgrave Macmillan, : 2009.,
面頁冊數:	viii, 239 p. ;23 cm.;
叢書名:	Science, technology, and medicine in modern history
標題:	Drug receptors - History. -
電子資源:	access to fulltext (Palgrave)
ISBN:	9780230583740

A short history of the drug receptor concept
Prèull, Cay-Rèudiger.

A short history of the drug receptor concept[electronic resource] /Cay-Rèudiger Prèull, Andreas-Holger Maehle, Robert Francis Halliwell. - Basingstoke [England] ;Palgrave Macmillan,2009. - viii, 239 p. ;23 cm. - Science, technology, and medicine in modern history.

Includes bibliographical references and index.

Paul Ehrlich and his receptor concept -- The development of the concept of drug receptors in the physiological research of J.N. Langley -- The receptors and scientific pharmacology I : the critics of the receptor idea and alternative theories of drug action, c. 1905-1935 -- The receptors and scientific pharmacology II : the critics of the receptor idea and alternative research strands : thetransmitter theory, c. 1905-1935 -- Quantitative arguments for the existence of drug receptors and the development of the receptor occupancy theory, c. 1910-1960 -- The dual adrenaline receptor theory of Raymond P. Ahlquist (1914-1983) and its application in drug development between 1950 and 1970 -- The emergence of molecular pharmacology.

Humans have long used plant and animal extracts for their medicinal properties but until the end of the 19th century their actions were often explained in a speculative manner. The systematic study of drugs didnot begin until the 1860s, and the concept of receptors as the target of their effects in the body only emerged at the end of the 19th century from the brilliant and independent studies of John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915). This book address the people and the key discoveries that led to the development of the receptor concept and its impact on 20th-century medicine: A.J Clark in the 1930s, andlater E.J Ariens and R.P Stephenson in the 1950s provided the quantitative basis of drug receptor occupancy theory. R.P Ahlquist's investigations gave rise tothe proposal of receptor subtypes in 1948 and facilitated Sir James Black (and subsequently others)to apply the receptor concept to clinical therapy (beta blockers) in the mid 1960s. By the early 1980s, the first (acetylcholine) receptor had been isolated and cloned. Today, we recognize a large and diverse number of physiological receptors which can be delineated into 'receptor super-families' on the basis of their pharmacology and molecular properties. These receptors are now the focus of a multi-national, multi-billion dollar pharmaceutical industry. This book reveals that these successes were by no means foreseeable, since chance, coincidence, competition among scientists, and other factors played important roles in the history of the receptor concept.

Electronic reproduction.
Basingstoke, England :
Palgrave Macmillan,
2010.

Mode of access:World Wide Web.

ISBN: 9780230583740

Standard No.: 10.1057/9780230583740doiSubjects--Topical Terms:

305849
Drug receptors
--History.Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RM301.41 / .P78 2009

Dewey Class. No.: 615/.7

National Library of Medicine Call No.: 2009 I-506

A short history of the drug receptor concept
LDR:03740cmm 2200337Ia 4500 001 158900
003 OCoLC
005 20100709082041.0
006 m d
007 cr cn|
008 160219s2009 enk sb 001 0deng d
020 $a 9780230583740
020 $a 0230583741
024 7 $a 10.1057/9780230583740 $2 doi
035 $a (OCoLC)497767020
035 $a ocn497767020
040 $a UKPGM $b eng $c UKPGM $d EBLCP $d YDXCP
049 $a APTA
050 1 4 $a RM301.41 $b .P78 2009
060 1 4 $a 2009 I-506
060 1 4 $a QV 11.1 $b P971s 2009
082 0 4 $a 615/.7 $2 22
100 1 $a Prèull, Cay-Rèudiger. $3 305847
245 1 2 $a A short history of the drug receptor concept $h [electronic resource] / $c Cay-Rèudiger Prèull, Andreas-Holger Maehle, Robert Francis Halliwell.
260 $a Basingstoke [England] ; $a New York : $c 2009. $b Palgrave Macmillan,
300 $a viii, 239 p. ; $c 23 cm.
440 0 $a Science, technology, and medicine in modern history
504 $a Includes bibliographical references and index.
505 0 $a Paul Ehrlich and his receptor concept -- The development of the concept of drug receptors in the physiological research of J.N. Langley -- The receptors and scientific pharmacology I : the critics of the receptor idea and alternative theories of drug action, c. 1905-1935 -- The receptors and scientific pharmacology II : the critics of the receptor idea and alternative research strands : thetransmitter theory, c. 1905-1935 -- Quantitative arguments for the existence of drug receptors and the development of the receptor occupancy theory, c. 1910-1960 -- The dual adrenaline receptor theory of Raymond P. Ahlquist (1914-1983) and its application in drug development between 1950 and 1970 -- The emergence of molecular pharmacology.
520 $a Humans have long used plant and animal extracts for their medicinal properties but until the end of the 19th century their actions were often explained in a speculative manner. The systematic study of drugs didnot begin until the 1860s, and the concept of receptors as the target of their effects in the body only emerged at the end of the 19th century from the brilliant and independent studies of John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915). This book address the people and the key discoveries that led to the development of the receptor concept and its impact on 20th-century medicine: A.J Clark in the 1930s, andlater E.J Ariens and R.P Stephenson in the 1950s provided the quantitative basis of drug receptor occupancy theory. R.P Ahlquist's investigations gave rise tothe proposal of receptor subtypes in 1948 and facilitated Sir James Black (and subsequently others)to apply the receptor concept to clinical therapy (beta blockers) in the mid 1960s. By the early 1980s, the first (acetylcholine) receptor had been isolated and cloned. Today, we recognize a large and diverse number of physiological receptors which can be delineated into 'receptor super-families' on the basis of their pharmacology and molecular properties. These receptors are now the focus of a multi-national, multi-billion dollar pharmaceutical industry. This book reveals that these successes were by no means foreseeable, since chance, coincidence, competition among scientists, and other factors played important roles in the history of the receptor concept.
533 $a Electronic reproduction. $b Basingstoke, England : $c Palgrave Macmillan, $d 2010. $n Mode of access:World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Jan. 11, 2010). $n Access may be restricted to users at subscribing institutions.
650 0 $a Drug receptors $x History. $3 305849
650 1 2 $a Receptors, Drug $x history. $3 305850
650 2 2 $a Biomedical Research $x history. $3 305851
650 2 2 $a History, 19th Century. $3 205386
650 2 2 $a History, 20th Century. $3 205385
650 2 2 $a Pharmacology $x history. $3 305852
655 7 $a Electronic books. $2 local. $3 96803
700 1 $a Maehle, Andreas-Holger, $d 1957- $3 305734
700 1 $a Halliwell, Robert Francis, $d 1957- $3 305848
710 2 $a Palgrave Connect (Online service) $3 227469
776 1 $c Original $z 9780230554153 $z 0230554156 $w (DLC) 2008030447 $w (OCoLC)154788769
856 4 0 $3 Palgrave Connect $u http://www.palgraveconnect.com/doifinder/10.1057/9780230583740 $z access to fulltext (Palgrave)