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McAlpine's multiple sclerosis

Record Type:	Electronic resources : Monograph/item
Title/Author:	McAlpine's multiple sclerosis/ Alastair Compston ... [et al.].
remainder title:	Multiple sclerosis
other author:	Compston, Alastair.
Published:	Philadelphia :Churchill Livingstone Elsevier, : 2005.,
Description:	x, 982 p. :ill. (some col.) ; : 29 cm.;
Subject:	Multiple sclerosis. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780443072710

McAlpine's multiple sclerosis
McAlpine's multiple sclerosis[electronic resource] /Multiple sclerosisAlastair Compston ... [et al.]. - 4th ed. - Philadelphia :Churchill Livingstone Elsevier,2005. - x, 982 p. :ill. (some col.) ;29 cm.

Includes bibliographical references (p. 811-946) and index.

SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS -- 1. The story of multiple sclerosis -- The evolving concept of multiple sclerosis -- Naming and classifying the disease: 1868-1983 -- Clinical descriptions of multiple sclerosis: 1838-1981 -- Personal accounts of multiple sclerosis: 1824-1991 -- The social history of multiple sclerosis: 1945-1998 -- The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977 -- The laboratory science of multiple sclerosis: 1912-1981 -- Discovery of glia and remyelination: 1858-1988 -- The aetiology of multiple sclerosis: 1883-1976 -- Attitudes to the treatment of multiple sclerosis: 1841-1983 -- SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS -- 2. The distribution of multiple sclerosis -- The rationale for epidemiological studies in multiple sclerosis -- Definitions and statistics in epidemiology -- Strategies for epidemiological studies in multiple sclerosis -- The geography of multiple sclerosis -- Epidemics and clusters of multiple sclerosis -- The environmental factor in multiple sclerosis -- 3. The genetics of multiple sclerosis: -- Genetic analysis of multiple sclerosis -- Methods of genetic analysis -- Racial susceptibility -- Sex differences in susceptibility -- Familial multiple sclerosis -- Candidate genes in multiple sclerosis -- Systematic genome screening -- Lessons from genetic studies of experimental allergic encephalomyelitis -- Conclusions -- 4. The natural history of multiple sclerosis -- Introduction -- Definitions -- Onset -- Course -- Inter-individual variability -- Factors affecting the prognosis -- General considerations -- Environmental influences -- Chapter 5: The aetiology of multiple sclerosis: an epitome -- SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS -- 6. The symptoms and signs of multiple sclerosis. -- Multiple sclerosis as a neurological illness -- Initial symptoms -- Symptoms and signs in the course of the disease -- Individual symptoms and sign -- Associated diseases -- Conclusion -- 7. The diagnosis of multiple sclerosis -- Diagnostic criteria for multiple sclerosis -- Selection of investigations -- Magnetic resonance imaging -- Evoked potentials -- Examination of the cerebrospinal fluid -- A strategy for the investigation of demyelinating disease -- 8. The differential diagnosis of multiple sclerosis -- The spectrum of disorders mimicking multiple sclerosis -- Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course -- Systematized central nervous system diseases -- Isolated or monosymptomatic CNS syndromes -- Non organic symptoms -- How accurate is the diagnosis of multiple sclerosis? -- 9. Multiple sclerosis in the individual and in groups: a conspectus -- The typical case -- Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria -- Co-morbidity and associated diseases -- Situations in which alternative diagnoses should be considered -- When to ignore b3 sinconvenient b4 s laboratory results or clinical findings: taking the best position -- b3 sPathognomonic b4 s and b3 sun-heard of b4 s features of multiple sclerosis -- SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS -- 10. The neurobiology of multiple sclerosis. -- Organisation in the central nervous system -- Development of the central nervous system -- Macroglial lineages in the rodent and human nervous system -- Axon-glial interactions and myelination -- Demyelination -- Axon degeneration and restoration of function -- Remyelination -- 11. The immunology of inflammatory demyelinating disease -- Multiple sclerosis as an autoimmune disease -- Immune responses: innate and adaptive -- T lymphocytes -- B lymphocytes -- Autoimmunity and self tolerance in the central nervous system -- Regulation of central nervous system autoimmune responses -- Immune reactivity in the central nervous system -- Pathogenesis of demyelination and tissue damage -- Peripheral blood biomarkers for multiple sclerosis and disease activity -- Markers of multiple sclerosis and disease activity in cerebrospinal fluid -- Conclusion -- 12. The pathology of multiple sclerosis -- Introduction -- Pathological classification of demyelinating diseases -- The demyelinated plaque -- Immunopathology of inflammation -- Demyelination and oligodendroglial damge -- Remyelination -- Axonal pathology -- Grey matter pathology / cortical plaques -- Astroglia reaction -- Abnormalities in the b3 snormal b4 s white matter -- Distribution of lesions in the nervous system -- Is there evidence for an infectious agent in the lesions of multiple sclerosis? -- Dynamic evolution of multiple sclerosis pathology -- Differences between acute relapsing and progressive multiple sclerosis -- Molecular approaches to the study of the MS lesion: Global profiling of transcriptome and proteome. -- Association of multiple sclerosis with other diseases -- Conclusions -- 13. The pathophysiology of multiple sclerosis -- Introduction -- Methods for exploring the pathophysiology of multiple sclerosis -- Relapsing remitting multiple sclerosis: loss of function due to conduction block -- Relapsing remitting multiple sclerosis: recovery of function and remission -- Physiological explanations for other clinical symptoms in multiple sclerosis -- Permanent loss of function in the context of disease progression -- Summary -- SECTION FIVE: THE TREATMENT OF MULTIPLE SCLEROSIS -- 15. Care of the person with multiple sclerosis -- General approach to the care of people with multiple sclerosis -- The early stages of disease: minimal disability -- The middle stages of disease: moderate disability -- The later stages of disease: severe disability -- Guidelines for the management and investigation of multiple sclerosis -- Conclusion -- 16. Treatment of the acute relapse -- The features of active multiple sclerosis -- The treatment of relapse in multiple sclerosis -- Other approaches to the treatment of acute relapse -- Treatment of acute optic neuritis -- Management of other central nervous system demyelinating disorders -- Adverse effects of corticosteroids -- Mode of action of corticosteroids -- Practice Guidelines -- 17. The treatment of symptoms in multiple sclerosis and the role of rehabilitation -- The general principles of symptomatic treatment in multiple sclerosis -- Disturbances of autonomic function -- Mobility and gait disturbance -- Fatigue -- Disturbances of brain stem function -- Perturbations of nerve conduction -- Cognition -- Visual symptoms -- Rehabilitation in multiple sclerosis -- Summary -- 18. Disease modifying treatments in multiple sclerosis -- The aims of disease modifying treatment -- The principles of evidence based prescribing in multiple sclerosis -- The role of magnetic resonance imaging in clinical trials -- Drugs that stimulate the immune response -- Drugs that non-specifically suppress the immune response -- The beta interferons -- Molecules that inhibit T cell-peptide binding -- Specific treatments that target T cells -- Agents which inhibit macrophages and their mediators -- Recent miscellaneous treatments -- Postscript -- 19: The person with multiple sclerosis: present and future -- Empirical versus hypothesis driven therapeutics -- New opportunities for immunological intervention -- Axon protection; acute and chronic -- Treatment in special situations -- Remyelination: -- Index.

Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition). Reviews the earliest clinical and pathological descriptions of multiple sclerosis. Offers a very strong section on pathogenesis. Includes more than 550 high-quality illustrations clarifying important scientific and clinical concepts. Uses a remarkably clear presentation to make complicated data as easy as possible to understand.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2009.

Mode of access: World Wide Web.

ISBN: 9780443072710

Source: 31935:31937Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

121660
Multiple sclerosis.
Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RC377 / .M43 2005

Dewey Class. No.: 616.8/34

McAlpine's multiple sclerosis
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300 $a x, 982 p. : $b ill. (some col.) ; $c 29 cm.
504 $a Includes bibliographical references (p. 811-946) and index.
505 0 $a SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS -- 1. The story of multiple sclerosis -- The evolving concept of multiple sclerosis -- Naming and classifying the disease: 1868-1983 -- Clinical descriptions of multiple sclerosis: 1838-1981 -- Personal accounts of multiple sclerosis: 1824-1991 -- The social history of multiple sclerosis: 1945-1998 -- The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977 -- The laboratory science of multiple sclerosis: 1912-1981 -- Discovery of glia and remyelination: 1858-1988 -- The aetiology of multiple sclerosis: 1883-1976 -- Attitudes to the treatment of multiple sclerosis: 1841-1983 -- SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS -- 2. The distribution of multiple sclerosis -- The rationale for epidemiological studies in multiple sclerosis -- Definitions and statistics in epidemiology -- Strategies for epidemiological studies in multiple sclerosis -- The geography of multiple sclerosis -- Epidemics and clusters of multiple sclerosis -- The environmental factor in multiple sclerosis -- 3. The genetics of multiple sclerosis: -- Genetic analysis of multiple sclerosis -- Methods of genetic analysis -- Racial susceptibility -- Sex differences in susceptibility -- Familial multiple sclerosis -- Candidate genes in multiple sclerosis -- Systematic genome screening -- Lessons from genetic studies of experimental allergic encephalomyelitis -- Conclusions -- 4. The natural history of multiple sclerosis -- Introduction -- Definitions -- Onset -- Course -- Inter-individual variability -- Factors affecting the prognosis -- General considerations -- Environmental influences -- Chapter 5: The aetiology of multiple sclerosis: an epitome -- SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS -- 6. The symptoms and signs of multiple sclerosis. -- Multiple sclerosis as a neurological illness -- Initial symptoms -- Symptoms and signs in the course of the disease -- Individual symptoms and sign -- Associated diseases -- Conclusion -- 7. The diagnosis of multiple sclerosis -- Diagnostic criteria for multiple sclerosis -- Selection of investigations -- Magnetic resonance imaging -- Evoked potentials -- Examination of the cerebrospinal fluid -- A strategy for the investigation of demyelinating disease -- 8. The differential diagnosis of multiple sclerosis -- The spectrum of disorders mimicking multiple sclerosis -- Diseases that may cause multiple lesions of the CNS and also often follow a relapsing remitting course -- Systematized central nervous system diseases -- Isolated or monosymptomatic CNS syndromes -- Non organic symptoms -- How accurate is the diagnosis of multiple sclerosis? -- 9. Multiple sclerosis in the individual and in groups: a conspectus -- The typical case -- Isolated syndromes and their outcome: judicious use of investigations and critique of the new diagnostic criteria -- Co-morbidity and associated diseases -- Situations in which alternative diagnoses should be considered -- When to ignore b3 sinconvenient b4 s laboratory results or clinical findings: taking the best position -- b3 sPathognomonic b4 s and b3 sun-heard of b4 s features of multiple sclerosis -- SECTION FOUR: THE PATHOGENESIS OF MULTIPLE SCLEROSIS -- 10. The neurobiology of multiple sclerosis. -- Organisation in the central nervous system -- Development of the central nervous system -- Macroglial lineages in the rodent and human nervous system -- Axon-glial interactions and myelination -- Demyelination -- Axon degeneration and restoration of function -- Remyelination -- 11. The immunology of inflammatory demyelinating disease -- Multiple sclerosis as an autoimmune disease -- Immune responses: innate and adaptive -- T lymphocytes -- B lymphocytes -- Autoimmunity and self tolerance in the central nervous system -- Regulation of central nervous system autoimmune responses -- Immune reactivity in the central nervous system -- Pathogenesis of demyelination and tissue damage -- Peripheral blood biomarkers for multiple sclerosis and disease activity -- Markers of multiple sclerosis and disease activity in cerebrospinal fluid -- Conclusion -- 12. The pathology of multiple sclerosis -- Introduction -- Pathological classification of demyelinating diseases -- The demyelinated plaque -- Immunopathology of inflammation -- Demyelination and oligodendroglial damge -- Remyelination -- Axonal pathology -- Grey matter pathology / cortical plaques -- Astroglia reaction -- Abnormalities in the b3 snormal b4 s white matter -- Distribution of lesions in the nervous system -- Is there evidence for an infectious agent in the lesions of multiple sclerosis? -- Dynamic evolution of multiple sclerosis pathology -- Differences between acute relapsing and progressive multiple sclerosis -- Molecular approaches to the study of the MS lesion: Global profiling of transcriptome and proteome. -- Association of multiple sclerosis with other diseases -- Conclusions -- 13. The pathophysiology of multiple sclerosis -- Introduction -- Methods for exploring the pathophysiology of multiple sclerosis -- Relapsing remitting multiple sclerosis: loss of function due to conduction block -- Relapsing remitting multiple sclerosis: recovery of function and remission -- Physiological explanations for other clinical symptoms in multiple sclerosis -- Permanent loss of function in the context of disease progression -- Summary -- SECTION FIVE: THE TREATMENT OF MULTIPLE SCLEROSIS -- 15. Care of the person with multiple sclerosis -- General approach to the care of people with multiple sclerosis -- The early stages of disease: minimal disability -- The middle stages of disease: moderate disability -- The later stages of disease: severe disability -- Guidelines for the management and investigation of multiple sclerosis -- Conclusion -- 16. Treatment of the acute relapse -- The features of active multiple sclerosis -- The treatment of relapse in multiple sclerosis -- Other approaches to the treatment of acute relapse -- Treatment of acute optic neuritis -- Management of other central nervous system demyelinating disorders -- Adverse effects of corticosteroids -- Mode of action of corticosteroids -- Practice Guidelines -- 17. The treatment of symptoms in multiple sclerosis and the role of rehabilitation -- The general principles of symptomatic treatment in multiple sclerosis -- Disturbances of autonomic function -- Mobility and gait disturbance -- Fatigue -- Disturbances of brain stem function -- Perturbations of nerve conduction -- Cognition -- Visual symptoms -- Rehabilitation in multiple sclerosis -- Summary -- 18. Disease modifying treatments in multiple sclerosis -- The aims of disease modifying treatment -- The principles of evidence based prescribing in multiple sclerosis -- The role of magnetic resonance imaging in clinical trials -- Drugs that stimulate the immune response -- Drugs that non-specifically suppress the immune response -- The beta interferons -- Molecules that inhibit T cell-peptide binding -- Specific treatments that target T cells -- Agents which inhibit macrophages and their mediators -- Recent miscellaneous treatments -- Postscript -- 19: The person with multiple sclerosis: present and future -- Empirical versus hypothesis driven therapeutics -- New opportunities for immunological intervention -- Axon protection; acute and chronic -- Treatment in special situations -- Remyelination: -- Index.
520 $a Since 1955, this landmark masterwork has been revered for its authoritative presentation of the entire state of scientific and clinical knowledge about multiple sclerosis. The state-of-the-art 4th Edition presents the most recent information on the genetics and epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Amply illustrated and referenced and beautifully written, McAlpine's Multiple Sclerosis has been described as "A standard reference for multiple sclerosis researchers, embryonic 'MS-ologists' and hard-pressed clinical neurologists alike" (Brain, review of the last edition). Reviews the earliest clinical and pathological descriptions of multiple sclerosis. Offers a very strong section on pathogenesis. Includes more than 550 high-quality illustrations clarifying important scientific and clinical concepts. Uses a remarkably clear presentation to make complicated data as easy as possible to understand.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2009. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Oct. 26, 2009). $n Access may be restricted to users at subscribing institutions.
650 0 $a Multiple sclerosis. $3 121660
650 1 2 $a Multiple Sclerosis. $3 321548
655 4 $a Electronic books. $2 local. $3 96803
700 1 $a Compston, Alastair. $3 321547
710 2 $a ScienceDirect (Online service) $3 254709
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