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Blood substitutes

Record Type:	Electronic resources : Monograph/item
Title/Author:	Blood substitutes/ edited by Robert M. Winslow.
other author:
Published:	Amsterdam ;Elsevier Academic Press, : c2006.,
Description:	xx, 548 p. :ill. ; : 28 cm.;
Subject:
ISBN:	9780127597607

Blood substitutes
Blood substitutes[electronic resource] /edited by Robert M. Winslow. - Amsterdam ;Elsevier Academic Press,c2006. - xx, 548 p. :ill. ;28 cm.

BACKGROUND -- Historical Background -- Transfusion Medicine -- Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice -- PHYSIOLOGICAL BASIS -- Clinical Physiology: Oxygen Transport and the Transfusion Trigger -- The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-Free Hemoglobins -- Oxygen Transport Properties of Hemoglobin- Based Oxygen Carriers: Studies Using Artificial Capillaries and Mathematical Stimulation -- Mechanisms of O2 Transport in the Microcirculation: Effects of Cell-Free O2 Carriers -- Shear Stress, Mechanotransduction and the Flow Properties of Blood -- Local Regulation of Blood Flow -- CLINICAL APPLICATIONS -- Clinical Indications for Blood Substitutes and Optimal Properties -- Crystalloid Solutions -- Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care -- Surgical Hemorrhage -- Clinical Trials in Cardiac Surgery -- Hemodilution -- Clinical Hemodilution -- Potential for Blood Substitutes in Tissue Ischemia -- TOXICITY AND SIDE EFFECTS -- Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies -- Pro-oxidant Activity of Hemoglobin and Endothelial Cytotoxicity -- Renal Toxicity -- Hemoglobin and Neurotoxicity -- The Role of Inflammation in the Toxicity of Hemoglobin-based Oxygen Carriers -- Hemoglobin-Induced Myocardial Lesions -- PERFLUOROCARBON-BASED OXYGEN CARRIERS -- Fluorocarbon Emulsions As In Vivo Oxygen Delivery Systems: Background And Chemistry -- Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier -- Perftoran -- Rational Development of Oxyfluor -- Oxygent, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients -- HEMOGLOBIN-BASED OXYGEN CARRIERS -- The Structural and Functional Properties of Hemoglobin and their Relevance for a Hemoglobin-based Blood Substitute -- Hemoglobin Modification -- Designing Recombinant Hemoglobin for Use as a Blood Substitute -- Design, Conformational, Functional, and Physiological Characterization of Recombinant Polymeric Heme-Proteins --�� -Crosslinked Hb -- DCLHb and rHb1.1 -- Studies with DCLHb -- Hemopure?[Hboc-201, Hemoglobin Glutamer-250 (Bovine)]: Preclinical Studies -- Hboc-201, [Hemoglobin Glutamer-250 (Bovine), Hemopure�]: Clinical Studies -- Polyhemoglobin-Enzymes as New Generation Blood Substitutes and Oxygen Therapeutics -- Surface Decoration of Hemoglobin with Polyethylene Glycol -- Hemospan (MP4), a Human Hemoglobin Modified with Maleimide-Polyethylene Glycol -- Dextran-Hemoglobin -- Development of Non-extravasating, Hemoglobin-Based Oxygen Carriers -- LIPOSOMES AND RELATED PRODUCTS -- Liposome Encapsulated Hemoglobin: History, Preparation, and Evaluation -- Hemoglobin-Vesicles as a Molecular Assembly:Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers -- Nanodimension Biodegradable Polymeric Membrane Artificial Red Blood Cells -- Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier -- GLOSSARY -- INDEX.#

Blood substitutes are solutions designed for use in patients who need blood transfusions, but for whom whole blood is not available, or is not safe. This interest has intensified in the wake of the AIDS and hepatitis C epidemics. Blood Substitutes describes the rationale, current approaches, clinical efficacy, and design issues for all blood substitutes now in clinical trials. The many summary diagrams and tables help make the book accessible to readers such as surgeons and blood bankers, who have less technical expertise than the biochemists and hematologists who are designing and testing blood substitutes. * Includes chapters necessary to the understanding of blood substitutes, including history, toxicity, physiology, and clinical applications * Presents detailed descriptions of the various products that have been developed and have advanced to clinical trials, and some that are in earlier states of development.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780127597607

Source: 85474:85474Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

72593

Index Terms--Genre/Form:

239592

LC Class. No.: RM171.7 / .B562 2006eb

Dewey Class. No.: 615/.399

National Library of Medicine Call No.: 2006 B-532

Blood substitutes
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037 $a 85474:85474 $b Elsevier Science & Technology $n http://www.sciencedirect.com
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245 0 0 $a Blood substitutes $h [electronic resource] / $c edited by Robert M. Winslow.
260 $a Amsterdam ; $a Boston : $c c2006. $b Elsevier Academic Press,
300 $a xx, 548 p. : $b ill. ; $c 28 cm.
505 0 $a BACKGROUND -- Historical Background -- Transfusion Medicine -- Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice -- PHYSIOLOGICAL BASIS -- Clinical Physiology: Oxygen Transport and the Transfusion Trigger -- The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-Free Hemoglobins -- Oxygen Transport Properties of Hemoglobin- Based Oxygen Carriers: Studies Using Artificial Capillaries and Mathematical Stimulation -- Mechanisms of O2 Transport in the Microcirculation: Effects of Cell-Free O2 Carriers -- Shear Stress, Mechanotransduction and the Flow Properties of Blood -- Local Regulation of Blood Flow -- CLINICAL APPLICATIONS -- Clinical Indications for Blood Substitutes and Optimal Properties -- Crystalloid Solutions -- Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care -- Surgical Hemorrhage -- Clinical Trials in Cardiac Surgery -- Hemodilution -- Clinical Hemodilution -- Potential for Blood Substitutes in Tissue Ischemia -- TOXICITY AND SIDE EFFECTS -- Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies -- Pro-oxidant Activity of Hemoglobin and Endothelial Cytotoxicity -- Renal Toxicity -- Hemoglobin and Neurotoxicity -- The Role of Inflammation in the Toxicity of Hemoglobin-based Oxygen Carriers -- Hemoglobin-Induced Myocardial Lesions -- PERFLUOROCARBON-BASED OXYGEN CARRIERS -- Fluorocarbon Emulsions As In Vivo Oxygen Delivery Systems: Background And Chemistry -- Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier -- Perftoran -- Rational Development of Oxyfluor -- Oxygent, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients -- HEMOGLOBIN-BASED OXYGEN CARRIERS -- The Structural and Functional Properties of Hemoglobin and their Relevance for a Hemoglobin-based Blood Substitute -- Hemoglobin Modification -- Designing Recombinant Hemoglobin for Use as a Blood Substitute -- Design, Conformational, Functional, and Physiological Characterization of Recombinant Polymeric Heme-Proteins --�� -Crosslinked Hb -- DCLHb and rHb1.1 -- Studies with DCLHb -- Hemopure?[Hboc-201, Hemoglobin Glutamer-250 (Bovine)]: Preclinical Studies -- Hboc-201, [Hemoglobin Glutamer-250 (Bovine), Hemopure�]: Clinical Studies -- Polyhemoglobin-Enzymes as New Generation Blood Substitutes and Oxygen Therapeutics -- Surface Decoration of Hemoglobin with Polyethylene Glycol -- Hemospan (MP4), a Human Hemoglobin Modified with Maleimide-Polyethylene Glycol -- Dextran-Hemoglobin -- Development of Non-extravasating, Hemoglobin-Based Oxygen Carriers -- LIPOSOMES AND RELATED PRODUCTS -- Liposome Encapsulated Hemoglobin: History, Preparation, and Evaluation -- Hemoglobin-Vesicles as a Molecular Assembly:Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers -- Nanodimension Biodegradable Polymeric Membrane Artificial Red Blood Cells -- Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier -- GLOSSARY -- INDEX.#
520 $a Blood substitutes are solutions designed for use in patients who need blood transfusions, but for whom whole blood is not available, or is not safe. This interest has intensified in the wake of the AIDS and hepatitis C epidemics. Blood Substitutes describes the rationale, current approaches, clinical efficacy, and design issues for all blood substitutes now in clinical trials. The many summary diagrams and tables help make the book accessible to readers such as surgeons and blood bankers, who have less technical expertise than the biochemists and hematologists who are designing and testing blood substitutes. * Includes chapters necessary to the understanding of blood substitutes, including history, toxicity, physiology, and clinical applications * Presents detailed descriptions of the various products that have been developed and have advanced to clinical trials, and some that are in earlier states of development.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on July 25, 2007). $n Access may be restricted to users at subscribing institutions.
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700 $q (Greta Eva Nina) $e 作. $3 98101
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