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Target validation in drug discovery

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	Target validation in drug discovery/ editors, Brian W. Metcalf and Susan Dillon.
其他作者:	Metcalf, Brian W.
出版者:	Amsterdam ;Academic Press, : c2007.,
面頁冊數:	xii, 279 p. :ill. ; : 27 cm.;
標題:	Drug development. -
電子資源:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123693938

Target validation in drug discovery
Target validation in drug discovery[electronic resource] /editors, Brian W. Metcalf and Susan Dillon. - Amsterdam ;Academic Press,c2007. - xii, 279 p. :ill. ;27 cm.

Includes bibliographical references and index.

Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches.

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780123693938

Source: 113098:113186Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

120365
Drug development.
Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RM301.63 / .T36 2007eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2006 N-124

Target validation in drug discovery
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505 0 $a Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches.
520 $a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
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