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High throughput analysis for early drug discovery

Record Type:	Electronic resources : Monograph/item
Title/Author:	High throughput analysis for early drug discovery/ edited by James N. Kyranos.
other author:	Kyranos, James N.
Published:	Amsterdam ;Elsevier, : 2004.,
Description:	xv, 186 p. :ill. (some col.) ; : 24 cm.;
Subject:	High throughput screening (Drug development) -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780124311657

High throughput analysis for early drug discovery
High throughput analysis for early drug discovery[electronic resource] /edited by James N. Kyranos. - 1st ed. - Amsterdam ;Elsevier,2004. - xv, 186 p. :ill. (some col.) ;24 cm.

Includes bibliographical references and index.

High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags, Adolor Corporation. -- Analysis of a Combinatorial Library Synthesized Using a Split-and-pool Irori MicroKan Method for Development and Production, Boehringer Ingelheim Pharmaceuticals, Inc. -- High-Throughput Mass Spectrometry-Flow Injection Analysis, Procter and Gamble Pharmaceuticals. -- High-Throughput Flow-Injection ESI and APCI Mass Spectrometry for Combinatorial Chemistry: Automated Acquisition and Interpretation for Multi-Sprayer Low-Resolution and FTMS High-Resolution Exact-Mass Measurements, Wyeth Research. -- Purity and Quantity Determination of Parallel Synthesis Compound Libraries, ArQule, Inc. -- High-Throughput Parallel LC/MS/ELSD of Combinatorial Libraries Using the Eight-Channel LCT System With MUX Technology, Nereus Pharmaceuticals Inc and University of California, San Diego. -- -- Purification and Analysis of Parallel Libraries, Albany Molecular. -- Screening Single Bead Combinatorial Libraries Using Capillary HPLC and MALDI-TOF-MS, National Research Council. -- The Role of NMR in the Analysis of Chemical Libraries, Bristol Meyers Squibb.

This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780124311657

Source: 88107:88107Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

201456
High throughput screening (Drug development)
Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RS419.5 / .H535 2004eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2006 A-375

High throughput analysis for early drug discovery
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245 0 0 $a High throughput analysis for early drug discovery $h [electronic resource] / $c edited by James N. Kyranos.
250 $a 1st ed.
260 $a Amsterdam ; $a Boston : $c 2004. $b Elsevier,
300 $a xv, 186 p. : $b ill. (some col.) ; $c 24 cm.
504 $a Includes bibliographical references and index.
505 0 $a High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags, Adolor Corporation. -- Analysis of a Combinatorial Library Synthesized Using a Split-and-pool Irori MicroKan Method for Development and Production, Boehringer Ingelheim Pharmaceuticals, Inc. -- High-Throughput Mass Spectrometry-Flow Injection Analysis, Procter and Gamble Pharmaceuticals. -- High-Throughput Flow-Injection ESI and APCI Mass Spectrometry for Combinatorial Chemistry: Automated Acquisition and Interpretation for Multi-Sprayer Low-Resolution and FTMS High-Resolution Exact-Mass Measurements, Wyeth Research. -- Purity and Quantity Determination of Parallel Synthesis Compound Libraries, ArQule, Inc. -- High-Throughput Parallel LC/MS/ELSD of Combinatorial Libraries Using the Eight-Channel LCT System With MUX Technology, Nereus Pharmaceuticals Inc and University of California, San Diego. -- -- Purification and Analysis of Parallel Libraries, Albany Molecular. -- Screening Single Bead Combinatorial Libraries Using Capillary HPLC and MALDI-TOF-MS, National Research Council. -- The Role of NMR in the Analysis of Chemical Libraries, Bristol Meyers Squibb.
520 $a This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on July 25, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a High throughput screening (Drug development) $3 201456
650 0 $a Combinatorial chemistry. $3 201520
650 1 2 $a Combinatorial Chemistry Techniques $x methods. $3 268437
650 2 2 $a Drug Evaluation, Preclinical $x methods. $3 199958
650 2 2 $a Pharmaceutical Preparations $x analysis. $3 201503
655 7 $a Electronic books. $2 local. $3 96803
700 1 $a Kyranos, James N. $3 322291
710 2 $a ScienceDirect (Online service) $3 254709
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856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780124311657 $z An electronic book accessible through the World Wide Web; click for information
994 $a C0 $b TEF