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Medicinal chemistry of anticancer drugs

Record Type:	Electronic resources : Monograph/item
Title/Author:	Medicinal chemistry of anticancer drugs/ Carmen Avenda�no and J. Carlos Men�endez.
Author:	Avenda�no, Carmen.
other author:	Men�endez, J. Carlos
Published:	Amsterdam ;Elsevier, : 2008.,
Description:	xv, 442 p. :ill. ; : 25 cm.;
Subject:	Cancer - Chemotherapy. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780444528247

Medicinal chemistry of anticancer drugs
Avenda�no, Carmen.

Medicinal chemistry of anticancer drugs[electronic resource] /Carmen Avenda�no and J. Carlos Men�endez. - 1st ed. - Amsterdam ;Elsevier,2008. - xv, 442 p. :ill. ;25 cm.

Includes bibliographical references and index.

1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.

Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780444528247

Source: 114030:114121Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

71989
Cancer
--Chemotherapy.Index Terms--Genre/Form:

96803
Electronic books.

LC Class. No.: RC271.C5 / A94 2008eb

Dewey Class. No.: 616.994061

Medicinal chemistry of anticancer drugs
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505 0 $a 1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10.Other approaches to targeted therapy -- 11.Drug targeting in anticancer chemotherapy -- 12.Resistance to antitumour agents and drugs that modulate it -- 13.Cancer chemoprevention.
505 0 $a Introduction -- Antimetabolites -- Anticancer drugs that inhibit hormone action -- Anticancer drugs acting via radical species, photosensitizers and photodynamic therapy of cancer -- DNA alkylating agents -- Alkylating and non-alkylating compounds interacting with the DNA minor groove -- DNA intercalators and topoisomerase inhibitors -- Anticancer drugs targeting tubulin and microtubules -- Drugs that inhibit signalling pathways for tumor cell growth and proliferation -- Other approaches to targeted therapy -- Drug targeting in anticancer chemotherapy -- Drugs that modulate resistance to antitumor agents -- Cancer chemoprevention.
520 $a Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature.
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