新生學校財團法人新生醫護管理專科學校圖書館 |

Language: English

Back

Advances in medicinal chemistry.. Vo...

Advances in medicinal chemistry.. Volume 4

Record Type:	Electronic resources : Monograph/item
Title/Author:	Advances in medicinal chemistry./
other author:
Published:	[S.l.] :Elsevier Science, : 1999.,
Description:	1 v.
Subject:
ISBN:	9780762300648

Advances in medicinal chemistry.. Volume 4
Advances in medicinal chemistry.Volume 4[electronic resource]. - [S.l.] :Elsevier Science,1999. - 1 v.

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol?(paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.#0

ISBN: 9780762300648

Source: 122678:127510Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

72593

Index Terms--Genre/Form:

239592

LC Class. No.: RS400 / .A35eb v. 4

Dewey Class. No.: 615/.19

Advances in medicinal chemistry.. Volume 4
LDR:01958cmm 2200253Ia 4500 001 165998
003 OCoLC
005 20110615082934.0
006 m d
007 cr cn|||||||||
008 160223s1999 xx o 000 0 eng d
020 $a 9780762300648
020 $a 0762300647
029 1 $a NZ1 $b 12433807
035 $a (OCoLC)166344357
035 $a ocn166344357
037 $a 122678:127510 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $c OPELS $d OPELS
049 $a TEFA
050 1 4 $a RS400 $b .A35eb v. 4
082 0 4 $a 615/.19 $2 22
245 0 0 $a Advances in medicinal chemistry. $n Volume 4 $h [electronic resource].
260 $a [S.l.] : $c 1999. $b Elsevier Science,
300 $a 1 v.
520 $a Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol?(paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.#0
650 0 $3 72593
655 7 $3 239592
700 $q (Greta Eva Nina) $e 作. $3 98101
710 $3 251528