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Advances in medicinal chemistry.. Vo...

Advances in medicinal chemistry.. Volume 4

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	Advances in medicinal chemistry./
其他作者:
出版者:	[S.l.] :Elsevier Science, : 1999.,
面頁冊數:	1 v.
標題:
ISBN:	9780762300648

Advances in medicinal chemistry.. Volume 4
Advances in medicinal chemistry.Volume 4[electronic resource]. - [S.l.] :Elsevier Science,1999. - 1 v.

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol?(paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.#0

ISBN: 9780762300648

Source: 122678:127510Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

72593

Index Terms--Genre/Form:

239592

LC Class. No.: RS400 / .A35eb v. 4

Dewey Class. No.: 615/.19

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