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3D cell-based biosensors in drug discovery programs = microtissue engineering for high throughput screening /

紀錄類型:	書目-電子資源 : 單行本
正題名/作者:	3D cell-based biosensors in drug discovery programs/ William S. Kisaalita.
其他題名:	microtissue engineering for high throughput screening /
作者:	Kisaalita, William Ssempa,
出版者:	Boca Raton [Fla.] :CRC Press, : 2010.,
面頁冊數:	466 p.
標題:	High throughput screening (Drug development) -
電子資源:	Distributed by publisher. Purchase or institutional license may be required for access.
ISBN:	9781420073508 (e-book : PDF)

3D cell-based biosensors in drug discovery programs = microtissue engineering for high throughput screening /
Kisaalita, William Ssempa,1953-

3D cell-based biosensors in drug discovery programsmicrotissue engineering for high throughput screening /[electronic resource] :William S. Kisaalita. - Boca Raton [Fla.] :CRC Press,2010. - 466 p.

Includes bibliographical references and index.

(Publisher-supplied data) Biosensors and Bioassays -- Target-Driven Drug Discovery -- Comparative Genomics and Proteomics -- Comparative Structure and Function -- Chemical Microenvironmental Factors -- Spatial and Temporal Microenvironmental Factors -- Material Physical Property and Force Microenvironmental Factors -- Proteomics as a Promising Tool in the Search for 3D Biomarkers -- Readout Present and Near Future -- Ready-to-Use Commercial 3D Plates -- Challenges to Adopting 3D Cultures in HTS Programs -- Cases for 3D Cultures in Drug Discovery -- Ideal Case Study Design.

"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.

Mode of access: World Wide Web.

ISBN: 9781420073508 (e-book : PDF)Subjects--Topical Terms:

201456
High throughput screening (Drug development)
Index Terms--Genre/Form:

96803
Electronic books.

3D cell-based biosensors in drug discovery programs = microtissue engineering for high throughput screening /
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260 $a Boca Raton [Fla.] : $c 2010. $b CRC Press,
300 $a 466 p.
504 $a Includes bibliographical references and index.
505 8 $a (Publisher-supplied data) Biosensors and Bioassays -- Target-Driven Drug Discovery -- Comparative Genomics and Proteomics -- Comparative Structure and Function -- Chemical Microenvironmental Factors -- Spatial and Temporal Microenvironmental Factors -- Material Physical Property and Force Microenvironmental Factors -- Proteomics as a Promising Tool in the Search for 3D Biomarkers -- Readout Present and Near Future -- Ready-to-Use Commercial 3D Plates -- Challenges to Adopting 3D Cultures in HTS Programs -- Cases for 3D Cultures in Drug Discovery -- Ideal Case Study Design.
520 $a "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
530 $a Also available in print edition.
538 $a Mode of access: World Wide Web.
650 0 $a High throughput screening (Drug development) $3 201456
650 0 $a Biosensors. $3 120916
650 0 $a Pharmaceutical biotechnology. $3 123227
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